Type II TRK inhibitor 1

CAS: F: C35H33F3N8O3 W: 670.68

Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Ty

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Bioactivity	Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKAG667C and ETV6-TRKCG696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively[1].
Invitro	Type II TRK inhibitor 1 (compound 7b) (3.1-800 nM; 2 h) 抑制 TRKA，PLCγ1 和 ERK 的磷酸化[1]。 Western Blot Analysis[1] Cell Line:
Name	Type II TRK inhibitor 1
Formula	C35H33F3N8O3
Molar Mass	670.68
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang Z, et al. Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance. J Med Chem. 2022 Apr 28;65(8):6325-6337.